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Rottlerin: Bases for a Possible Usage in Psoriasis

[ Vol. 11 , Issue. 5 ]

Author(s):

Emanuela Maioli and Giuseppe Valacchi   Pages 425 - 430 ( 6 )

Abstract:


Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC δ inhibitor and recently proposed and patented as an anti-hypertensive drug. In vitro results from our Laboratory and data from the literature suggest a potential use of Rottlerin in the treatment/control of psoriasis, a skin disease characterized by abnormal cellular proliferation, abnormal angiogenesis and inflammation. Rottlerin, indeed, is an antioxidant and a potent inhibitor of the transcription factor NFκB, a key mediator of immune responses and a crucial regulator of cell cycle and apoptosis in immune cells, endothelial cells and keratinocytes. Herein, we will review the multiple activities of Rottlerin (antioxidant, antiproliferative, antiangiogenic and anti-inflammatory) that give to the drug the potential to be used as a new therapeutic approach against psoriasis.

Keywords:

Rottlerin, NFκB, Inflammation, Angiogenesis, Proliferation

Affiliation:

Department of Biomedical Sciences; Via Aldo Moro, 7 - 53100 SIENA, Italy.



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