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Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs

Author(s):

Phuong H.L. Tran and Thao T.D. Tran*  

Abstract:


Clays have been used in various health care products, including drug delivery systems. Advanced formulations have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of clays, such as high adsorption, high surface area, and high ion exchange capacities, provide an ideal system for the delivery of poorly water-soluble drugs. There is currently limited information on the classification and discussion of clay-based formulations for poorly water-soluble drugs. This review aims to describe efficient delivery systems that use clay as the main excipient in formulations. More details about the strategies of using clays in formulations as well as fabrication methods will be discussed. Moreover, combinations with other excipients in hybrid formulations will also be mentioned in evaluating the efficacy of these systems. The highlighted recent studies on clay-based formulations for poorly water-soluble drugs could provide fundamental approaches and prospects to apply them in drug development.

Keywords:

Clay-based formulations, clay, poorly water-soluble drugs, drug delivery, dissolution enhancement, adsorption

Affiliation:

Deakin University, School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Geelong, Institute of Research and Development, Duy Tan University, Danang 550000



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