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New horizons in the treatment of neurological disorders with tailorable gold nanoparticles

Author(s):

Farheen Danish, Md. Asad Khan*, Ghulam Md Ashraf, Anwar L. Bilgrami and M. Moshahid A. Rizvi  

Abstract:


Neurological disorders, such as epilepsy, dementia, Parkinson’s disease, and Alzheimer’s disease, occur due to disorganization of the neurons in the nervous system. Disturbances in the nervous system cause problems with memory, senses and moods. In order to treat such disorders, scientists have been working extensively by using different approaches. Nanoneurotechnology has emerged as a promising tool to manage these complicated disorders, where nanoparticles with their tunable properties such as size, shape, increased solubility, biodegradability, surface area and sharp penetration through the biological barriers target the central nervous system. This technology targets damaged neurons without affecting healthy neurons and Blood-Brain Barrier (BBB). In this review, we discuss neurological disorders and challenges in the diagnosis and treatment of neurological disorders by emphasizing the role of tailorable gold nanoparticles for therapeutic drug approaches.

Keywords:

Neurodegeneration, Blood Brain Barrier, Nanotechnology, Gold nanoparticles, Neurological disorders, Therapeutic drug approaches

Affiliation:

Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Department of Biosciences, Jamia Millia Islamia, New Delhi



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