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Nano Phytomedicine Based Delivery System for CNS Disease

[ Vol. 21 , Issue. 9 ]


Mohammed Asadullah Jahangir, Chettupalli Anand, Abdul Muheem, Sadaf Jamal Gilani*, Mohamad Taleuzzaman, Ameeduzzafar Zafar, Mohammed Jafar, Surajpal Verma and Md. Abul Barkat   Pages 661 - 673 ( 13 )


Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.


Nano formulation, phytomedicine, central nervous system, neurodegenerative disorder, nano-phytomedicines, herbal medicine.


Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Rajgir, Nalanda-803116, Bihar, Department of Pharmaceutics, Anurag Group of Institutions, School of Pharmacy, Venkatapur, Ghatkesar, Telangana-500088, Department of Pharmaceutics, Faculty of Pharmacy, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, College of Basic Health Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Faculty of Pharmacy, Maulana Azad University, Jodhpur 342802, Rajasthan, Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Al Jamiah, Hafr Al Batin- 39524

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