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Meta-analysis of NFKB1-94 ATTG Ins/Del Polymorphism and Risk of Breast Cancer

[ Vol. 21 , Issue. 3 ]

Author(s):

Jyothsna Kancharla, I. Devi Vara Prasad, Lakkakula V.K.S. Bhaskar*, Pallaval Veera Bramhachari* and Afroz Alam*   Pages 221 - 225 ( 5 )

Abstract:


Background: Breast cancer (BC) accounts for one of the most prevalent malignancies in the world. Inflammatory molecules modulate tumor microenvironment in BC that promotes tumor growth and metastasis. NF-κB (a transcription factor) that regulates multiple immune functions and acts as a crucial mediator of inflammatory responses.

Objective: The present study is aimed to quantitatively summarize the relation of NFKB1-94 ATTG (I, insertion/D, deletion) variant and risk of BC.

Methods: Further, the meta-analysis includes three independent case-control investigations that focus on NFKB1-94, ATTG I/D polymorphism, and BC patients. Web of Science, PubMed and Embase databases were used to retrieve relevant data. OR and 95% confidence interval of pooled studies were analyzed by using the MetaGenyo web tool.

Results: This study revealed a high heterogeneity. In all three genetic comparison models, the NFKB1-94 ATTG I/D variant is not related to the risk of BC. Further, no publication bias on the connection between NFKB1-94 ATTG I/D variant and risk of BC was observed.

Conclusion: To summarize, our meta-analysis demonstrates that the NFKB1-94 ATTG I/D polymorphism is not a major risk factor for BC.

Keywords:

Breast cancer, inflammation, NFKB1-94, ATTG I/D polymorphism, meta-analysis, transcription factor.

Affiliation:

Department of Bioscience and Biotechnology, Banasthali University, Vanasthali, Rajasthan 304022, Department of Physical Education and Sports Sciences, Acharya Nagarjuna University, Ongole 523001, Andhra Pradesh, Department of Zoology, Guru Ghasidas University, Bilaspur 495009, Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh 521001, Department of Bioscience and Biotechnology, Banasthali University, Vanasthali, Rajasthan 304022

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