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Versatile and Valuable Utilization of Amidohydrolase L-glutaminase in Pharma and Food industries: A Review

[ Vol. 21 , Issue. 1 ]

Author(s):

Chandrasai Potla Durthi*, Madhuri Pola, Satish Babu Rajulapati*, Anand Kishore Kola and Mohammad Amjad Kamal   Pages 11 - 24 ( 14 )

Abstract:


L-glutaminase has versatile applications in pharma and food industries. In pharmaceutical industry, L-glutaminase can be used as anti-oxidant and anti-cancer agent to treat Acute Lymphocytic Leukaemia (ALL). Whereas, in the food industry, L-glutaminase is used for acrylamide degradation, theanine production, flavour enhancer, soy sauce and many. The other applications include nitrogen metabolism and its use as biosensor in hybridoma technology. Both intra-cellular and extra-cellular L-glutaminases from wide range of sources were identified. Because of its diverse applications, there is a need to improve the production of L-glutaminase by enzyme engineering technology. Effect of recombination on L-glutaminase production was also reported. Researchers also confirmed the antitumor properties of L-glutaminase by conducting in vitro, in vivo and in silico studies. Bacillus sps. and Aspergillus sps. are the commercial producers of L-glutaminase. In this review, the applications, different sources of Lglutaminase, anti-cancer properties were discussed.

Keywords:

Acute lymphocytic leukaemia (ALL), L-glutaminase, therapeutic enzyme, production, optimization, enzyme engineering, food industry, pharma industry, biosensor, acrylamide, in vitro, in vivo, in silico studies.

Affiliation:

Department of Biotechnology, National Institute of Technology Warangal, Telangana 506004, Department of Biotechnology, National Institute of Technology Warangal, Telangana 506004, Department of Biotechnology, National Institute of Technology Warangal, Telangana 506004, Department of Chemical Engineering, National Institute of Technology Warangal, Telangana 506004, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589

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