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Antiplatelet Potential of Plant-Derived Glycosides as Possible Lead Compounds

[ Vol. 19 , Issue. 10 ]

Author(s):

Haroon Khan*, Aini Pervaiz, Mohammad A. Kamal and Seema Patel   Pages 856 - 862 ( 7 )

Abstract:


Background: Blood platelets are crucial for maintaining hemostasis and several events in the woundhealing. However, platelet up-regulation leads to the development and the complications of several cardiovascular diseases. For the effective management of these complications, several synthetic drugs are in clinical practice such as aspirin, warfarin and other drugs. since a long time. But some adverse reactions like aspirin resistance and bleed disorders cause patient incompliance and reduce their therapeutic potential. Thus, the search for potent and safer antiplatelet agents is of great interest.

Methods: Various search engines such as Google, GoogleScholar, PubMed and ScienceDirect were used for the search of antiplatelet glycosides. All peered review journals were considered in the review.

Results: Glycoside is a class of naturally-occurring organic compounds that are frequently found in the plant kingdom. Similarly, platelet aggregation beyond the purpose of hemostasis is the underlying cause of blood clottingrelated diseases. The results showed strong potential of plant derived glycosides in various preclinical studies.

Conclusions: This review presents a thorough understanding of plant-derived glycosides as antiplatelet agents with a possible mechanism of action based on the existing literature. In addition, this review discusses the possibility of formulating antiplatelet medications from plant glycosides with strong safety profile. On the basis of strong finding, clinical studies are recommended to ascertain their therapeutic utility.

Keywords:

Medicinal plants, glycosides, antiplatelet, possible mechanisms, safety profile, lead compounds.

Affiliation:

Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, King Fahd Medical Research Center, King Abdulaziz University, Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, CA 92182

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