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Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease

[ Vol. 18 , Issue. 7 ]

Author(s):

Antonio Bellasi*, Andrea Galassi, Michela Mangano, Luca Di Lullo and Mario Cozzolino   Pages 680 - 688 ( 9 )

Abstract:


Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.

Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of vitamin D receptor modulation aside from parathyroid hormone control.

Keywords:

CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.

Affiliation:

Renal and Dialysis Division Ospedale Sant’Anna-Como, ASST-Lariana, Via Ravona, 20 – 22020 Como, Department of Health Sciences, Renal Division, San Paolo Hospital, University of Milan, Milan, Department of Health Sciences, Renal Division, San Paolo Hospital, University of Milan, Milan, UOC di Nefrologia e Dialisi, Ospedale Parodi Delfino, Colleferro (Roma), Department of Health Sciences, Renal Division, San Paolo Hospital, University of Milan, Milan

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