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Exploration of Various Proteins for the Treatment of Alzheimer's Disease

[ Vol. 18 , Issue. 9 ]

Author(s):

Badar ul Islam, Syed Kashif Zaidi, Mohammad Amjad Kamal and Shams Tabrez*   Pages 808 - 813 ( 6 )

Abstract:


Background: Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement are the patho-physiological marker of this devastated disease

Objective: In view of limited treatment option and their success rate, there is an urgent need to explore the vast array of proteomes for the management of AD. These proteins could be therapeutically targeted to prevent the progression of this disease. In the present review, we tried to uncover several proteins that could be exploited in AD therapeutics.

Conclusion: Based on our article, we conclude that proteome based AD treatment needs more refinements and approaches to achieve the desired success rate.

Keywords:

Alzheimer's disease, amyloid beta, amyloid precursor protein, apolipoprotein, tau, therapeutics.

Affiliation:

Department of Biochemistry, J. N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589

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