Alexiou Athanasios, Vairaktarakis Charalampos, Tsiamis Vasileios and Ghulam Md. Ashraf Pages 5 - 10 ( 6 )
Background: The investigation of the cellular components, their interactions and related functions constitute the major conditions in order to understand the cell as an integrated system. More specifically, the Protein-Protein Interactions and the obtained networks are very important in the majority of biological functions and processes, while most of the proteins appear to activate their functionalities through their interaction.Methods: Our in depth review analysis, include Sixty-five peer-reviewed research and review studies from several bibliographic databases. The most significant components were fully described, filtered, combined and analyzed in order to provide documented proofs on the Protein-Protein Interaction Network' applications in biomedicine. Results: The Protein-Protein Interaction Network' alignment and mapping give the opportunity of further knowledge extraction concerning the evolutionary relationships between the species through conserved pathways and protein complexes. Additionally, Protein-Protein Interaction Network information has been demonstrated to be able to predict functionally orthologous proteins within sequence homology clusters. Our review analysis concluded that, while Protein- Protein Interaction was used to be characterized just by their large and plain interacting surfaces, they were considered inapplicable for drug discovery studies for a long time. Conclusion: The present review explores multiple technologies implicated in Protein-Protein Interaction Networks, implicating their potential role in drug discovery mechanisms.
Drug discovery, global network alignment, local network alignment, protein-protein interaction network, yeast two-hybrid system.
Novel Global Community Educational Foundation, School of Science,, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589