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Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies

[ Vol. 17 , Issue. 5 ]


Riccardo Pofi, Francesca Di Mario, Antonietta Gigante, Edoardo Rosato, Andrea M. Isidori, Antonio Amoroso, Rosario Cianci and Biagio Barbano   Pages 497 - 502 ( 6 )


Background: Diabetic nephropathy (DN) is currently the most common cause of end-stage renal disease (ESRD). Although nowadays much is known about its classification, pathogenesis, clinical manifestations and evolution, to date we are not yet able to stop the natural progression of nephropathy in diabetic patients.

Methods: Treatment options are: lifestyle change with close blood pressure monitoring and tight glycemic control. The most common therapies adopted for this condition are Angiotensing Converting Enzyme-inhibitors (ACEi). However these drugs are able to block the progression of renal damage only in a small proportion of patients. In the remaining, DN progresses and may evolve into ESRD.

Conclusion: The purpose of this review is to summarize the “state of art” of current novel therapeutic strategies to stem this debilitating kidney disease.


Chronic kidney disease, diabetes mellitus, diabetic nephropathy, end stage renal disease, novel therapies.


Department of Clinical Medicine, Sapienza University of Rome,Viale del Policlinico 15500161 - Rome - Italy.

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