Magisetty Obulesu and Magisetty Jhansilakshmi Pages 142 - 149 ( 8 )
Background: Alzheimer's disease (AD) is a devastative neurodegenerative disorder with a complex etiology. Despite numerous novel nanotechnology methods targeted against cancer and neurodegenerative diseases such as AD in the past decade, several challenges impeded their success.
Objective: We ventured to circumvent these challenges by synthesizing redox nanoparticles (RNP) such as Nitroxide radical, 2,2,6,6 tetramethylpiperidinyl-N-oxyl (TEMPO). Piperine in association with RNP successfully scavenges reactive oxygen species (ROS). Our studies have also shown that the piperine associated with RNP confers enhanced protection against AD in vitro.
Conclusion: This review summarizes our recent findings on the protective roles of redox nanoparticles both in vitro and in vivo. In addition, vital role of nanoparticles employed to encapsulate natural compounds such as curcumin and metal chelators has been summarized. We warrant further studies in animal models using these protective nanoparticles.
Alzheimer’s disease, curcumin, metal chelators, Redox nanoparticles.
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan.