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Nanocarriers for Anticancer Drugs - New Trends in Nanomedicine

[ Vol. 14 , Issue. 5 ]

Author(s):

Jana Drbohlavova, Jana Chomoucka, Vojtech Adam, Marketa Ryvolova, Tomas Eckschlager, Jaromir Hubalek and Rene Kizek   Pages 547 - 564 ( 18 )

Abstract:


This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.

Keywords:

Nanotechnologies, nanoparticles, gene therapy, anticancer drugs, drug carriers, cancer, cytostatic, targeted therapy.

Affiliation:

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.



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