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Utility of Assessing Thiopurine S-methyltransferase Polymorphisms Before Azathioprine Therapy

[ Vol. 13 , Issue. 9 ]

Author(s):

Teresa Cabaleiro, Manuel Roman, Javier P. Gisbert and Francisco Abad-Santos   Pages 1277 - 1293 ( 17 )

Abstract:


Thiopurine S-methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs, such as azathioprine and mercaptopurine, which are used in a variety of diseases. Several mutations in the TPMT gene correlate with low enzyme activity and subsequent adverse effects, mainly myelotoxicity. Hence, genotyping TPMT makes it possible to identify patients at high risk of drug toxicity and adjust dosage accordingly. However, further research about the availability of a reliable and universal screening method and more costeffectiveness studies are necessary.

Keywords:

Thiopurine S-methyltransferase, azathioprine, polymorphism, genotyping

Affiliation:

Service of Clinical Pharmacology, Hospital Universitario de la Princesa, 28006 Madrid, Spain.



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