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Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...

[ Vol. 7 , Issue. 3 ]

Author(s):

Andras Palotas and Janos Kalman   Pages 273 - 293 ( 21 )

Abstract:


Alzheimers disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.

Keywords:

Allele, Alzheimer's disease, determinative gene, linkage analysis, polymorphism, risk factor, risk gene, susceptibility gene

Affiliation:

University ofSzeged, H-6720 Szeged, Pecsi u. 4, Hungary.



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