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Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders

[ Vol. 22 , Issue. 4 ]

Author(s):

Aashish Sharma*, Romila Manchanda, Faheem H. Pottoo and Ghulam Md. Ashraf   Pages 251 - 262 ( 12 )

Abstract:


Impressive research steps have been taken for the treatment of neurological disorders in the last few decades. Still, effective treatments of brain related disorders are very less due to problems associated with crossing the blood-brain barrier (BBB), non-specific therapies, and delay in functional recovery of the central nervous system (CNS) after treatment. Striving for novel treatment options for neurological disorders, nanotechnology- derived materials, and devices have gained ground due to inherent features of derivatization/encapsulation with drugs as per the neurological ailments and pharmacological targets. Facile developments/syntheses of the nanomaterials-drug conjugates have also been the driving force for researchers to get into this field. Moreover, the tunable size and hydro/lipophilicity of these nanomaterials are the added advantages that make these materials more acceptable for CNS disorders. These nano-neurotherapeutics (NNTs) systems provide the platform for diagnosis, theranostics, treatments, restoration of CNS disorders, and encourage the translation of NNTs from “bench to bedside”. Still, these techniques are in the primary stages of medical development. This review describes the latest advancements and future scenarios of developmental and clinical aspects of polymeric NNTs.

Keywords:

Nanoparticles, BBB, neuronal disorders, imaging, theranostics, drug delivery, cancer.

Affiliation:

SFI Centre for Research in Medical Devices (CÚRAM), National University of Ireland, Galway, Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr, East Lansing MI 48824, Department Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah

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