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Nanostructured Lipid Carriers (Nlcs): Nose-to-Brain Delivery and Theranostic Application

Author(s):

Javed Ahmad*, Md. Rizwanullah, Saima Amin, Musarrat Husain Warsi, Mohammad Zaki Ahmad and Md. Abul Barkat   Pages 1 - 11 ( 11 )

Abstract:


Background: Nanostructured lipid carriers (NLCs) are in high demand in the present pharmaceutical domain due to its high versatility. It is the newer generation of lipidic nanoparticulate systems having a solid matrix and greater stability at room temperature.

Objective: To review the evidence related to current state of the art of the NLCs system and its drug delivery perspectives to brain.

Methods: Scientific data search, review of current state of the art and drug delivery perspectives to brain for NLCs were undertaken to assess the applicability of NLCs in management of neurological disorders through intranasal route of drug administration.

Results: NLCs are designed to fulfill all the industrial needs like a simple technology, low cost, easily scale up and quantifications. Biodegradable and biocompatible lipids and surfactants used for NLCs made it acceptable with regulatory perspectives. Apart from these, NLCs have unique properties of high drug payload, modulation of drug release profile, minimum drug expulsion during storage, and incorporation in various dosage forms like gel, creams, granules, pellets, powders for reconstitution and colloidal dispersion. Ease of surface-modification of NLCs enhancing targeting efficiency with reduced systemic toxicity by providing site-specific delivery to the brain through the intranasal route of drug administration.

Conclusion: The present review encompasses the in-depth discussion over the current state of the art of NLCs, nose-tobrain drug delivery perspectives and its theranostic application as useful tools for better management of various neurological disorders. In addition, pharmacokinetic consideration and toxicity concern is also discussed specifically for the NLCs system exploited in nose-to-brain delivery.

Keywords:

Nanostructured lipid carriers, colloidal dispersion, nose-to-brain delivery, theranostic, neurological disorders, targeting efficiency.

Affiliation:

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif-Al-Haweiah 21974, Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Al Jamiah, Hafr Al Batin 39524



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