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Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling

Author(s):

Pobitra Borah, Sangeeta Hazarika, Satyendra Deka*, Katharigatta N. Venugopala, Anroop B. Nair, Mahesh Attimarad, Nagaraja Sreeharsha and Raghu Prasad Mailavaram   Pages 1 - 17 ( 17 )

Abstract:


The successful conversion of natural products (NPs) into lead compounds and novel pharmacophores have emboldened the researchers to harness the drug discovery process with lot more enthusiasm. However, forfeit of bioactive NPs resulting from overabundance of metabolites and their wide dynamic range have created the bottleneck in NP researches. Similarly, existence of multidimensional challenges including evaluation of pharmacokinetics, pharmacodynamics, and safety parameters has been a concerned issue for many. Advancement of technology has brought the evolution of traditional natural product researches into the computer-based assessment exhibiting pretentious remarks about their efficiency in the drug discovery. The early attention to the quality of the NPs may reduce the attrition rate of drug candidates by parallel assessment of ADMET profiling. This article reviews the status, challenges, opportunities, and integration of advanced technologies in natural product research. Indeed, emphasis will be on current and futuristic direction towards the application of newer technologies in early-stage ADMET profiling of bioactive moieties from the natural sources. It can be expected that combinatorial approaches in ADMET profiling will fortify the Natural Product-based drug discovery in the near future.

Keywords:

Natural Products, Drug Discovery, ADMET Profiling, Databases, Virtual Screening, In silico Methods, Traditional Medicines

Affiliation:

Pratiksha Institute of Pharmaceutical Sciences, Chandrapur Road, Panikhaiti, Guwahati-26, Assam, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh-221005, Pratiksha Institute of Pharmaceutical Sciences, Chandrapur Road, Panikhaiti, Guwahati-26, Assam, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Department of Pharmaceutical Chemistry, Shri Vishnu College of Pharmacy, Vishnupur (Affiliated to Andhra University), Bhimavaram, W.G. Dist., AP



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