Saleha Rehman, Bushra Nabi, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali* Pages 1 - 11 ( 11 )
Background: Neuropsychiatric diseases characterized primarily by dementia stand third in the global list of diseases causing disability. The poor water solubility, erratic oral absorption, low bioavailability, poor intestinal absorption, and the impeding action of the blood-brain barrier (BBB) are the major factors limiting the therapeutic feasibility of the antipsychotics. Only a negligible fraction of antipsychotics reaches the target therapeutic site which warrants administration of high doses consequently leading to unwanted side-effects. Hence the main struggle for the effective treatment of neuropsychiatric diseases occurs “at the gates” of the brain which can be mitigated with the use of nanotechnology-based platform.
Methods: The goal of this review is to undertake a comprehensive study about the role of lipid nanoformulations in facilitating the delivery of antipsychotics across BBB along with the available in vitro and in vivo evidences.
Results: Lipid nanoformulations have attained great heights for the delivery of therapeutics into the brain. Their nanosize helps in overcoming the biological barriers thereby providing easy BBB translocation of the drugs. Besides, they offer numerous advantages like controlled and targeted drug release, minimizing drug efflux, long storage stability, augmented bioavailability, and reduced adverse drug effects to achieve an optimum therapeutic drug concentration in the brain. Moreover, employing alternative routes of administration have also shown promising results.
Conclusion: Thus, it can be concluded that the lipid nanoformulations bear immense potential in overcoming the challenges associated with the treatment of neuropsychiatric disorders. However, the area warrants conduction of clinical studies to ensure their commercialization which could revolutionize the treatment of neuropsychiatric diseases in the coming decades.
Lipid Nanoparticles, schizophrenia, nanostructured lipid carrier, solid lipid nanoparticles, nanoemulsion, bioavailability, brain delivery.
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi110062, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi110062, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, Dammam, 31441, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi110062, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi110062