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Strong Association between Serotonin Transporter 5-HTTVNTR Variant and Psychoactive Substance (Nicotine) Use in the Turkish Cypriot Population

Author(s):

Emine Kandemis, Gulten Tuncel, Ozen Asut, Sehime G. Temel and Mahmut Cerkez Ergoren*   Pages 1 - 5 ( 5 )

Abstract:


Background: The use of psychoactive substances is one of the most dangerous social problems worldwide. Nicotine dependence results from the interaction between neurobiological, environmental and genetic factors. Serotonin is a neurotransmitter that has a wide range of central nervous system activities. The serotonin transporter gene has been previously linked to psychological traits.

Objective: A variable number of tandem repeats within the serotonin transporter-linked polymorphic gene region is believed to alter the transcriptional efficiency of the 5-HTT gene. Therefore, we aimed to investigate the association between this polymorphic site and smoking behavior in the Turkish Cypriot population.

Methods: A total of 259 (100 smokers, 100 non-smokers and 59 ex-smokers) Turkish Cypriots were included in this population-based cross-sectional study. Genomic DNA was extracted from peripheral blood samples and the 5-HTTVNTR2 polymorphisms were determined by the PCR-RFLP.

Results: The allelic frequency and genotype distribution results of this study showed a strong association (P<0.0001) between smokers and non-smokers. No statistical significance was found between non-smokers and ex-smokers.

Conclusion: This is the first genetic epidemiology study to investigate the allelic frequencies of 5-HTTVNTR2 polymorphisms associated with smoking behavior in the Turkish Cypriot population. Based on the results of this study, genome wide association studies should be designed for preventive medicine in this population.

Keywords:

Serotonin, nicotine, smoking, Cyprus, neurotransmitter agents, tobacco.

Affiliation:

Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahçeşehir University, 34353 Istanbul, Department of Medical Biology, Faculty of Medicine, Near East University, 99138, Nicosia, Department of Public Health, Faculty of Medicine, Near East University, 99138, Nicosia, Department of Public Health, Faculty of Medicine, Near East University, 99138, Nicosia, Department of Medical Biology, Faculty of Medicine, Near East University, 99138, Nicosia



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