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Evaluating Lean Liver Volume as a Potential Scaler for In vitro-In vivo Extrapolation of Drug Clearance in Obesity Using the Model Drug Antipyrine

Author(s):

Jaydeep Sinha*, Stephen B Duffull, Bruce Green and Hesham S Al-Sallami   Pages 1 - 5 ( 5 )

Abstract:


Background In vitro-in vivo extrapolation (IVIVE) of hepatic drug clearance (CL) involves the scaling of hepatic intrinsic clearance 〖〖CL〗_(int,u)〗_H by functional liver size, which is approximated by total liver volume (LV) as per the convention. However, in most overweight and obese patients, LV includes abnormal liver fat which is not thought to contribute to drug elimination, thus overestimating drug CL. Therefore, lean liver volume (LLV) might be a more appropriate scaler of 〖〖CL〗_(int,u)〗_H.

Objective The objective of this work was to assess the application of LLV in CL extrapolation in overweight and obese patients (BMI >25 kg/m2) using a model drug antipyrine.

Method Recently, a model to predict LLV from patient sex, weight, and height was developed and evaluated. In order to assess the LLV model’s use in IVIVE, a correlation based analysis was conducted using antipyrine as an example drug.

Results In the overweight group (BMI >25 kgm2), LLV could describe 36% of the variation in antipyrine CL (R^2=0.36), which was >2-fold higher than that was explained by LV (R^2=0.17). In the normal weight group (BMI ≤25 kg/m2) the coefficients of determination were 58% (R^2=0.58) and 43% (R^2=0.43) for LLV and LV respectively.

Conclusion The analysis indicates that LLV is potentially a more appropriate descriptor of functional liver size than LV, particularly in overweight individuals. Therefore, LLV has potential application in IVIVE of CL in obesity.

Keywords:

IVIVE, NAFLD, NASH, PBPK, FFM, drug development, obesity, liver volume, lean liver volume, functional liver volume.

Affiliation:

School of Pharmacy, University of Otago, Dunedin, School of Pharmacy, University of Otago, Dunedin, Model Answers R&D Pty Ltd, Brisbane, School of Pharmacy, University of Otago, Dunedin



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