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Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes

Author(s):

Menjivar Marta, Sánchez-Pozos Katy, Jaimes-Santoyo Joel, Monroy-Escutia Jazmin, Rivera-Santiago Carolina, Granados-Silvestre María de los Ángeles and Ortiz-López María Guadalupe*   Pages 1 - 10 ( 10 )

Abstract:


Background. In Mexico, approximately 25% of patients with type 2 diabetes (T2D) have adequate glycemic control. Polymorphisms in pharmacogenetic genes have been shown to have clinical consequences resulting in drug toxicity or therapeutic inefficacy.

Objective. To evaluate the impact of variants in genes known to be involved in the response to oral hypoglycemic drugs, such as CYP2C9, OCT, MATE, ABCA1 and C11orf65, in the Mexican Mestizo population of T2D patients.

Methods. In this study, 265 patients with T2D were enrolled from Hospital Juárez de México, Mexico City. Genotyping was performed by TaqMan® assays. SNP–SNP interactions were analyzed using the multifactor dimensionality reduction (MDR) method.

Results. Carriers of the del allele of rs72552763 could achieve a better glycemic control than noncarriers. There was a significant difference in plasma glucose and HbA1c levels among rs622342 genotypes. The results suggested a SNP-SNP interaction between rs72552763 and rs622342 OCT1 and rs12943590 MATE2.

Conclusion. The interaction between rs72552763 and rs622342 in OCT1, and rs12943590 in MATE2 suggested an important role of these polymorphisms in metformin response in T2D Mexican Mestizo population.

Keywords:

OCT, MATE, Mexican population, pharmacogenetics, polymorphism, allele frequency, oral hypoglycemic therapy

Affiliation:

Laboratorio de Diabetes, Facultad de Química de la Universidad Nacional Autónoma de México, Laboratorio de Endocrinología Molecular, Research Division, Hospital Juárez de México, Laboratorio de Endocrinología Molecular, Research Division, Hospital Juárez de México, Laboratorio de Endocrinología Molecular, Research Division, Hospital Juárez de México, Laboratorio de Endocrinología Molecular, Research Division, Hospital Juárez de México, Laboratorio de Diabetes, Facultad de Química de la Universidad Nacional Autónoma de México, Laboratorio de Endocrinología Molecular, Research Division, Hospital Juárez de México



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