Subashini Raman, Syed Mahmood*, Ayah R Hilles, M Noushad Javed, Motia Azmana and Khater Ahmed Saeed Al-Japairai Pages 1 - 12 ( 12 )
Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery.
Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs.
Results: We found that various different type of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation which includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain.
Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.
Brain delivery, polymer, nanoparticles, nanomedicine, biodistribution, nanomedicine
Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Kuantan, Pahang, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Kuantan, Pahang, Faculty of Health Sciences, Department of Medical Science and Technology, PICOMS International University College of Medical Sciences, 68100 Kuala Lumpur, School of Pharmaceutical sciences, Apeejay Stya University, New Delhi, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Kuantan, Pahang, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Kuantan, Pahang