Submit Manuscript  

Article Details


Human Papillomavirus Induced Cervical and Oropharyngeal Cancers: From Mechanisms to Potential Immuno-Therapeutic Strategies

Author(s):

Mohd Saeed*, Syed Mohd Faisal, Firoz Akhtar, Saheem Ahmad, Mousa M. Alreshidi, Mohd Adnan Kausar, Shadab Kazmi, Amir Saeed, Mohd Adnan and Ghulam Md Ashraf   Pages 1 - 11 ( 11 )

Abstract:


The human papillomavirus (HPV) associated infections are the hallmark of cervical and neck cancer. Almost all the cases of cervical cancer (CC) and 70% of oropharyngeal cancer (OC) are more or less caused by the persistent infection of HPV. CC is fourth most common cancer globally and is commenced by the persistent infection with human papillomaviruses (HPVs), predominantly HPV types; 16 and 18. In the light of above facts, there is an immediate requirement to develop novel preventive and innovative therapeutic strategies that may help in lower occurrences of HPV mediated cancers. Currently, only radiation and chemical-based therapies are the treatment for HPV mediated neck cancer (NC) and CC. Recent advances in the field of immunotherapy are underway, which are expected to unravel the optimal treatment strategies for the growing HPV mediated cancers. In this review, we decipher the mechanism of pathogenesis with current immunotherapeutic advances in regressing the NC and CC, with an emphasis of immune-therapeutic strategies being tested in clinical trials and predominantly focus on defining the efficacy and limitations. Taken together, these immunological advances have enhanced the effectiveness of immunotherapy and promises better treatment results in coming future.

Keywords:

Cervical Cancer, Human papillomaviruses (HPVs), HPV type 16 and 18, Immunotherapy, Neck Cancer, Oropharyngeal Cancer.

Affiliation:

Department of Biology, College of Sciences, University of Hail, Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, Department of Pharmacology and Toxicology, Higuchi Biosciences Center, University of Kansas, 2099 Constant Ave. Lawrence, KS, Department of Biosciences Integral University Lucknow, Department of Biology, College of Sciences, University of Hail, Department of Biochemistry College of Medicine University of Hail, Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, Department of Clinical Laboratory Sciences, University of Hail, Department of Biology, College of Sciences, University of Hail, KSA, King Fahd Medical Research Center, King Abdulaziz University, Jeddah



Read Full-Text article