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Frontier View on Nanotechnological Strategies for Neuro-therapy

[ Vol. 19 , Issue. 7 ]

Author(s):

Asim Azhar, Ghulam Md. Ashraf*, Qamar Zia, Shakeel A. Ansari, Asma Perveen, Abdul Hafeez, Mohd Saeed, Mohammad A. Kamal, Athanasios Alexiou, Magdah Ganash, Nagendra S. Yarla, Saleh S. Baeesa, Mohamed M. Alfiky and Osama S. Bajouh   Pages 596 - 604 ( 9 )

Abstract:


Background: Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain.

Objective: Nanotechnology based approaches (NBA) favours transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The last five years have witnessed the successful applications of NBA to treat neurological disorders. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders.

Conclusion: This review introduces the emerging work in this area and summarizes the successful NBA used in recent past for treating various neurological disorders ike Alzheimer’s disease, Parkinson's disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.

Keywords:

Alzheimer's disease, blood brain barrier, drug delivery, nanotechnology, nanotechnology based approaches, neurological disorders.

Affiliation:

Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago IL, 60064, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Department of Biotechnology, Gagan College of Management and Technology, Aligarh, UP, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Glocal School of Life Sciences, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, Department of Clinical Laboratory Sciences, College of Applied medical Sciences, University of Hail, Hail, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Novel Global Community Educational Foundation, Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Vishakhapatnam-530045, A.P, Division of Neurosurgery, College of Medicine, King Abdulaziz University, Jeddah, Division of Neurosurgery, College of Medicine, King Abdulaziz University, Jeddah, Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah

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