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Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

[ Vol. 19 , Issue. 8 ]

Author(s):

Sidra Batool*, Nighat Noureen and Mohammad Amjad Kamal   Pages 714 - 720 ( 7 )

Abstract:


Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.

Keywords:

Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.

Affiliation:

Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589

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