Fehmida Bibi, Muhammad Faheem, Esam I. Azhar, Muhammad Yasir, Sana A. Alvi, Mohammad A. Kamal, Ikram Ullah and Muhammad I. Naseer Pages 11 - 15 ( 5 )
Background: Sponges are rich source of bioactive natural products synthesized by the symbiotic bacteria belonging to different phyla. Due to a competition for space and nutrients the marine bacteria associated with sponges could produce more antibiotic substances. To explore the proactive potential of marine microbes extensive research has been done. These bioactive metabolites have some unique properties that are pharmaceutically important.Methods: For this review, we have performed a non-systematic search of the available literature though various online search engines. This review provides an insight that how majority of active metabolites have been identified from marine invertebrates of which sponges predominate. Results: Sponges harbor abundant and diverse microorganisms, which are the sources of a range of marine bioactive metabolites. From sponges and their associated microorganisms, approximately 5,300 different natural compounds are known. Current research on sponge-microbe interaction and their active metabolites has become a focal point for many researchers. Various active metabolites derived from sponges are now known to be produced by their symbiotic microflora. Conclusion: In this review, we attempt to report the latest studies regarding capability of bacteria from sponges as producers of bioactive metabolite. Moreover, these sponge associated bacteria are an important source of different enzymes of industrial significance. In present review, we will address some novel approaches for discovering marine metabolites from bacteria that have the greatest potential to be used in clinical treatments.
Antimicrobial activity, hydrolytic enzymes, marine sponges, secondary metabolites, sponge-associated bacteria.
Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University Jeddah 21589