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Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity

[ Vol. 14 , Issue. 2 ]

Author(s):

Laura Cuzzolin   Pages 167 - 173 ( 7 )

Abstract:


Physiological changes occurring perinatally and in the first month of life can affect the answer to a pharmacological treatment and the individual response to a drug in terms of efficacy and toxicity is highly variable in the neonatal population. Among potential causes for such variability, differences in drug metabolism may have a great impact.

This article aims to review qualitative and quantitative differences in drug metabolizing enzymes in neonates, since both phase I and phase II metabolic pathways are immature at birth and subject to maturational changes in the first period of extrauterine life.

Moreover, clinical implications will be discussed.

Keywords:

Newborns, drugs, enzymes, Drug Metabolizing Enzymes, Perinatal, Neonatal Period, toxicity, phase II, CYP2C, CYP3A5, Sulfation

Affiliation:

Department of Public Health & Community Medicine-Section of Pharmacology, University of Verona, Policlinico G.B. Rossi, Piazzale L.A. Scuro, 37134 Verona, Italy.



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